Page 45 - Hoag Orthopedic Institute 2017 Outcomes Report
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NeoCart Trial – When the cartilage around the knee is torn, the pain is excruciating. This study investigates how to  ll the “potholes” created by torn cartilage with a patient’s own cartilage cells. The two-part procedure, called NeoCart,  rst harvests tissue from the patient’s knee cartilage. Then, after growing new tissue in the lab, orthopedic surgeons  t the  nished membrane into the damaged cartilage. This procedure could replace the traditional treatment of drilling microfractures into the knee bone, which creates scar tissue and must be redone every 10 to 15 years. Thanks to trial sponsor Histogenics Corporation, all study-related surgical procedures, of ce visits and some rehabilitation costs are covered for participating patients.
Robert Grumet, MD, discussing the NeoCart Trial with ABC 7 Reporter Denise Dador.
OrthoGenomics – Personalized medicine through genomics holds the promise of allowing physicians to be more accurate in predicting and preventing musculoskeletal issues. Hoag Orthopedics is conducting the  rst study of its kind nationwide. The study examines how patients react to certain pain medications and anti-in ammatories as well as which patients might develop issues such as osteolysis or have a higher risk of infection.
By identifying genetic links to pain, range of motion and recovery, surgeons can best treat conditions for greater patient outcomes.
Camille Borges, clinical research coordinator, reviews a digital X-ray of a hip replacement patient.
Pain Journal Study – “A Prospective Look
at Narcotic Use Following Simple Knee Arthroscopy” – Sports Medicine Fellow Michael Dempewolf, DO, led this study that looks at
how genomics can predict a patient’s response to pain medication. By documenting and collecting data from 500 patients, the research team is creating a new standard for how much medication to prescribe to patients for optimal pain management.
Teddy Quilligan, clinical research coordinator, discusses clinical trials with a patient.

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